What does this research mean for the field?

The mangrove-derived fungus Aspergillus sp. SCSIO 41440 produces several newly discovered prenylated isoindolinone alkaloids and polyketides, and yields a specific compound (compound 10) that acts as a potent acetylcholinesterase inhibitor. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 27, 2026Marine Drugs0 citationsOpen Access

Novel Alkaloids and Polyketides From Mangrove-Derived Fungus Inhibit Acetylcholinesterase

New Prenylated Isoindolinone Alkaloids and Polyketides from the Mangrove-Derived Fungus Aspergillus sp. SCSIO 41440

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Authors

CYChun Yang YCYi Chen ZXZhifei Xiong

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Overview

In vitro study demonstrates potent acetylcholinesterase inhibition by a mangrove-derived fungal compound, highlighting potential scaffolds for drug development.

Key Points

To isolate and structurally characterize secondary metabolites from the mangrove-derived fungus Aspergillus sp. SCSIO 41440 and assess their acetylcholinesterase inhibitory activities.
Purified metabolites from Aspergillus sp. SCSIO 41440 and determined chemical structures using NMR, mass spectrometry, single-crystal X-ray diffraction, and electronic circular dichroism.
Assayed isolated compounds for in vitro acetylcholinesterase (AChE) inhibitory activity and modeled enzyme interactions using molecular docking (PDB: 4EY7).
Isolated six new metabolites—aspernidines C–E, protubonine C, (±)-asperisocoumarin J, and asperisocoumarin K—alongside six known compounds.
Identified compound 10 as an effective AChE inhibitor with an IC50 of 3.16 ± 1.16 μM.
Confirmed through molecular docking that compound 10 binds strongly within the AChE active site.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a8fe99e10c91c1e92621561 https://doi.org/10.3390/md24090297

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August 27, 2026Marine Drugs0 citationsOpen Access

Novel Alkaloids and Polyketides From Mangrove-Derived Fungus Inhibit Acetylcholinesterase

New Prenylated Isoindolinone Alkaloids and Polyketides from the Mangrove-Derived Fungus Aspergillus sp. SCSIO 41440

View Full Paper

Ask AI

Bookmark

Authors

CYChun Yang YCYi Chen ZXZhifei Xiong

Discussion

Member takes

Overview

In vitro study demonstrates potent acetylcholinesterase inhibition by a mangrove-derived fungal compound, highlighting potential scaffolds for drug development.

Key Points

To isolate and structurally characterize secondary metabolites from the mangrove-derived fungus Aspergillus sp. SCSIO 41440 and assess their acetylcholinesterase inhibitory activities.
Purified metabolites from Aspergillus sp. SCSIO 41440 and determined chemical structures using NMR, mass spectrometry, single-crystal X-ray diffraction, and electronic circular dichroism.
Assayed isolated compounds for in vitro acetylcholinesterase (AChE) inhibitory activity and modeled enzyme interactions using molecular docking (PDB: 4EY7).
Isolated six new metabolites—aspernidines C–E, protubonine C, (±)-asperisocoumarin J, and asperisocoumarin K—alongside six known compounds.
Identified compound 10 as an effective AChE inhibitor with an IC50 of 3.16 ± 1.16 μM.
Confirmed through molecular docking that compound 10 binds strongly within the AChE active site.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a8fe99e10c91c1e92621561 https://doi.org/10.3390/md24090297

View Full Paper

Ask AI

Bookmark