Serum soluble klotho in the systolic blood pressure intervention trial (SPRINT): comparison of two assays and correlation with kidney and mineral metabolism biomarkers

Q: What does this research mean for the field?

Different assays for measuring serum soluble klotho exhibit specific performance characteristics and correlations with kidney and mineral metabolism biomarkers in the SPRINT trial cohort. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

David A. Drew; Xilong Li; Tiffany H Chen; Johanne Pastor; Fabiola Gianella; Sachdev Sidhu; Orson W. Moe; Mark J. Sarnak; Joachim H Ix; Javier A. Neyra

doi:10.1093/ckj/sfag281

August 25, 2026Clinical Kidney JournalOpen Access

Serum soluble klotho in the systolic blood pressure intervention trial (SPRINT): comparison of two assays and correlation with kidney and mineral metabolism biomarkers

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Key Points

To compare two distinct assay methods for measuring serum soluble klotho and assess their correlations with biomarkers of kidney function and mineral metabolism in SPRINT participants.
Measured serum soluble klotho concentrations using two different assay platforms in participants from the Systolic Blood Pressure Intervention Trial (SPRINT).
Assessed correlations between assay-specific klotho measurements and clinical biomarkers of renal function and mineral metabolism.
Identified comparative performance characteristics and concordance between the two soluble klotho assay methods.
Characterized differential strengths of association between each klotho assay and established indicators of kidney disease and mineral homeostasis.

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Implication

Study substudy evaluates two soluble klotho assays in hypertension, suggesting distinct associations with kidney and mineral metabolism biomarkers.

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Cite This Study

Drew et al. (2026) studied this question.

synapsesocial.com/papers/6a8fe9ad10c91c1e92621715 https://doi.org/10.1093/ckj/sfag281

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Serum soluble klotho in the systolic blood pressure intervention trial (SPRINT): comparison of two assays and correlation with kidney and mineral metabolism biomarkers

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

Serum soluble klotho in the systolic blood pressure intervention trial (SPRINT): comparison of two assays and correlation with kidney and mineral metabolism biomarkers

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

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