Preclinical animal study demonstrates that APOE2 mitigates APOE4-driven amyloid pathology in mice, indicating protective molecular mechanisms against neurodegeneration.
This repository contains the analysis scripts used in the study investigating the effects of heterozygous APOE genotypes in a 5xFAD mouse model of amyloid pathology. The study examines how APOE2 and APOE4 influence amyloid deposition, glial responses, proteomic profiles, and lipidomic alterations, with particular focus on whether APOE2 is associated with attenuation of APOE4-related pathological and molecular changes in APOE2/4 mice.
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Chen et al. (2026) studied this question.
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