Special Issue “New Insights into Bioactive Peptides: Design, Synthesis, Structure–Activity Relationship (2nd Edition)”

Q: What does this research mean for the field?

Bioactive peptides represent a diverse and significant class of molecules whose applications can be advanced through ongoing research into their design, synthesis, and structure-activity relationships. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Flavia Anna Mercurio; Marilisa Leone

doi:10.3390/ijms27177587

August 25, 2026International Journal of Molecular SciencesOpen Access

Special Issue “New Insights into Bioactive Peptides: Design, Synthesis, Structure–Activity Relationship (2nd Edition)”

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Key Points

To compile and review cutting-edge strategies for designing, synthesizing, and evaluating structure–activity relationships of functional bioactive peptides.
Reviewed contemporary chemical synthesis and modification techniques for short- and medium-chain peptide sequences.
Evaluated computational modeling and structural optimization tools used to refine biological activity and metabolic stability.
Assessed in vitro and in vivo assays used to map structure–activity relationships across therapeutic peptide candidates.
Structural modifications, including backbone cyclization and non-natural amino acid incorporation, substantially improve peptide stability against proteolytic degradation.
Targeted sequence optimization enhances receptor-binding selectivity and biological potency across antimicrobial, anticancer, and metabolic applications.

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Implication

Review highlights recent advances in the chemical synthesis and structural modification of bioactive peptides, indicating expanding potential for targeted therapeutics.

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Cite This Study

Mercurio et al. (2026) studied this question.

synapsesocial.com/papers/6a8fe9b910c91c1e92621959 https://doi.org/10.3390/ijms27177587

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Special Issue “New Insights into Bioactive Peptides: Design, Synthesis, Structure–Activity Relationship (2nd Edition)”

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Special Issue “New Insights into Bioactive Peptides: Design, Synthesis, Structure–Activity Relationship (2nd Edition)”

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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