PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
August 27, 2026Acta cardiologica. Supplementum

Risk factors for poor prognosis in patients with acute ischaemic stroke: a retrospective study

View Full Paper
Ask AI
Bookmark
Share

Why the study?

This study aimed to investigate the risk factors for poor prognosis after thrombolysis and their predictive values in patients with large artery atherosclerosis.

What are the risk factors for poor prognosis in patients with acute ischaemic stroke and large artery atherosclerosis after intravenous thrombolysis?

Population

136 patients with acute ischaemic stroke receiving first-time intravenous alteplase

Comparison

Good prognosis (mRS <3) vs poor prognosis (mRS ≥3)

Design

Retrospective study

Follow-up

90 days after admission

Key result

Older age and higher NIHSS scores (AUC 0.730; 95% CI 0.646-0.814) were significant risk factors for poor prognosis at 90 days in patients with acute ischaemic stroke.

Authors

YSYan ShiYLYong-Tao LiuJSJingjing Sun

Discussion

Loading...

Member takes

Overview

Risk factors for poor post-thrombolysis outcomes in LAA stroke remain hypothesis-generating; prospective validation required before clinical application.

Key Points

  • To identify risk factors associated with poor 90-day prognosis and assess their predictive values in acute ischaemic stroke patients with large artery atherosclerosis receiving thrombolysis.
  • Retrospectively analyzed 136 patients with acute ischaemic stroke receiving intravenous alteplase thrombolysis for the first time.
  • Categorized patients into good prognosis (mRS < 3, n = 70) and poor prognosis (mRS ≥ 3, n = 66) groups based on outcomes at 90 days post-admission.
  • Older age (95% CI: 1.010–1.082) and higher post-thrombolysis NIHSS scores (95% CI: 1.093–1.312) independently increased the risk of poor prognosis, with significant differences also observed for hypertension and LDL-C levels (all p < 0.05).
  • Receiver operating characteristic analysis demonstrated predictive value for age (AUC = 0.657, 95% CI: 0.562–0.746, cut-off 66.50 years) and post-thrombolysis NIHSS score (AUC = 0.730, 95% CI: 0.646–0.814, cut-off 5.50 points).

Study Design

Type

Observational (n=136)

Structured PICO

What are the risk factors for poor prognosis in patients with acute ischaemic stroke and large artery atherosclerosis after intravenous thrombolysis?

P
Population
136 patients with acute ischaemic stroke and large artery atherosclerosis who underwent first-time intravenous thrombolysis with alteplase, evaluated for prognosis at 90 days.
O
Outcome
Poor prognosis defined as a modified Rankin Scale score ≥3 at 90 days after admissionhard clinical

Main Result

p-value: p=<0.05

Older age and higher NIHSS scores after thrombolysis are significant predictors of poor 90-day functional outcomes in patients with acute ischaemic stroke and large artery atherosclerosis.

Cite This Study

Shi et al. (2026) conducted an observational in Acute ischaemic stroke with large artery atherosclerosis (n=136). Older age and higher NIHSS scores was evaluated on Poor prognosis (modified Rankin Scale ≥3 at 90 days) (95% CI 1.093-1.312, p=<0.05). Older age and higher NIHSS scores (AUC 0.730; 95% CI 0.646-0.814) were significant risk factors for poor prognosis at 90 days in patients with acute ischaemic stroke.

synapsesocial.com/papers/6a8fe9c910c91c1e92621c03https://doi.org/10.1080/00015385.2026.2631266
View Full Paper
Ask AI
Bookmark
Share