Risk factors for poor prognosis in patients with acute ischaemic stroke: a retrospective study

Objective This study aimed to investigate the risk factors for poor prognosis after thrombolysis and their predictive values in patients with large artery atherosclerosis (LAA).Methods A total of 136 patients with acute ischaemic stroke who underwent intravenous thrombolysis with alteplase for the first time were retrospectively collected and divided into the ‘good prognosis’ group (n = 70) and the ‘poor prognosis’ group (n = 66) according to their score on the modified Rankin Scale (<3 or ≥3) at 90 days after admission. Related parameters were collected and compared.Results The differences between the two groups of patients were statistically significant in age, National Institutes of Health Stroke Scale (NIHSS) scores, hypertension and the level of low-density lipoprotein cholesterol (LDL-C) (all p < 0.05). Older age (95%CI: 1.010–1.082) and higher NIHSS scores after thrombolysis (95%CI: 1.093–1.312) were risk factors for poor prognosis after thrombolysis in patients with LAA. The area under the curve to predict these poor prognoses after thrombolysis was 0.657 (95%CI: 0.562–0.746) for age, with a cut-off value of 66.50 years, and 0.730 (95%CI: 0.646–0.814) for the NIHSS score, with a cut-off value of 5.50 points.Conclusions Older age and higher NIHSS scores after thrombolysis are risk factors for poor prognosis in patients with LAA, with certain predictive values.