Comparative analysis demonstrates conserved competitive neural connectivity across mammals, highlighting implications for neurodevelopment, aging, and clinical modeling.
Whole-brain models have long assumed purely cooperative brain connectivity, but Luppi et al. demonstrate that competitive couplings are a conserved feature of the mammalian connectome, markedly improving model accuracy across humans, macaques, and mice. This Comment examines the lifespan implications — from adolescent maturation of long-range competitive connections to their erosion in aging and neurodegeneration — and the framework’s translational potential for personalised brain models and clinical biomarkers.
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Pomeroy et al. (2026) studied this question.
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