Why the study?
Detection and identification of echovirus genotypes in clinical samples is challenging due to high genetic diversity, despite causing conditions such as aseptic meningitis, myocarditis, and acute flaccid paralysis.
Next-generation sequencing identified high genetic diversity and divergent strains of echoviruses in Brazilian children with gastroenteritis.
Echovirus genomes from Brazilian gastroenteritis cases leave myocarditis links open; extends regional surveillance data for future cardiac studies.
Echoviruses (E) are a diverse group of viruses responsible for various pathological conditions in humans including aseptic meningitis, myocarditis, and acute flaccid paralysis. The detection and identification of echovirus genotypes in clinical samples is challenging due to its high genetic diversity. Here, we report the complete genome sequences of nine echoviruses, obtained by next-generation sequencing of 238 fecal samples from individuals with gastroenteritis in regions of Brazil. Detected viruses were classified into six genotypes: Three E1 sequences (BRA/TO-028, BRA/TO-069 and BRA/TO-236), one E3 (BRA/TO-018), one E11 (BRA/TO-086), one E20 (BRA/TO-016), two E29 (BRA/TO-030 and BRA/TO-193), and one E30 sequence (BRA/TO-032). Phylogenetic analysis indicated that the echoviruses E1 and E29 circulating in Brazil are divergent from strains circulating worldwide. The genotype diversity identified in our study may under-represent the total echovirus diversity in Brazil because of the small sample size and the restricted geographical distribution covered by the survey.
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Ramos et al. (2021) studied this question.
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