OBJECTIVE: To determine the outcome of 113 women with vulvar intraepithelial neoplasia (VIN), particularly in reference to the later development of invasive vulvar carcinoma. METHODS: All cases of VIN III seen between 1961 and 1993 were reviewed. RESULTS: Seven of eight untreated cases of VIN III progressed to invasive vulvar cancer within 8 years, and the eighth regressed spontaneously. Four women developed invasive vulvar carcinoma 7-18 years after treatment. Thus, 3.8% of treated patients later developed invasive vulvar carcinoma, and 87.5% of untreated patients progressed to invasive carcinoma. CONCLUSION: There is a substantial risk that untreated VIN III will progress to invasive cancer.
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Jones et al. (1995) studied this question.