Extreme vertices designs are useful in experimentation with mixtures, particularly when the response can be described by a linear model. An algorithm is proposed for selecting a subset of extreme vertices when the number of candidate vertices is large. This algorithm has been found to produce designs which generally have small trace (X'X)−1, indicating the average variance of the estimated coefficients in the linear model will be small.
No takes yet. Share an insight, caveat, or question.
Snee et al. (1974) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: