Key result
In patients with impaired glucose tolerance, incident use of diuretics (HR 1.23; 95% CI 1.06-1.44) and statins (HR 1.32; 95% CI 1.14-1.48) was associated with increased risk of new-onset diabetes.
Why the study?
Do diuretics, beta blockers, and statins increase the risk of new onset diabetes in patients with impaired glucose tolerance?
Population
Patients with impaired glucose tolerance and other cardiovascular risk factors who were treatment naïve at…
Comparison
Initiation of β blockers, statins, or diuretics… vs Initiation of calcium channel blockers or non-use.
Design
Cohort
Follow-up
median five years
Authors
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Supports monitoring new diuretic or statin starts in impaired glucose tolerance; hypothesis-generating and requires randomized confirmation.
Cohort
Do diuretics, beta blockers, and statins increase the risk of new onset diabetes in patients with impaired glucose tolerance?
Hazard Ratio: 1.23 (95% CI 1.06–1.44)
In patients with impaired glucose tolerance, the initiation of diuretics and statins is associated with an increased risk of new-onset diabetes, whereas beta blockers and calcium channel blockers are not.
Shen et al. (2013) conducted a cohort in Impaired glucose tolerance. Diuretics and statins vs. Calcium channel blockers or non-use was evaluated on Development of new onset diabetes (HR 1.23, 95% CI 1.06 to 1.44). In patients with impaired glucose tolerance, incident use of diuretics (HR 1.23; 95% CI 1.06-1.44) and statins (HR 1.32; 95% CI 1.14-1.48) was associated with increased risk of new-onset diabetes.
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