Why the study?
What is the steady-state relative potency of prorenoate compared to spironolactone in healthy male subjects?
What is the steady-state relative potency of prorenoate compared to spironolactone in healthy male subjects?
Prorenoate is approximately 2.7 to 4.2 times more potent than spironolactone on a weight basis for mineralocorticoid antagonism at steady state.
May inform prorenoate dosing relative to spironolactone; extends steady-state potency data from this RCT.
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Mclnnes et al. (1981) studied this question.
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