An in vitro bioassay for hyaluronidase activity has been developed based on cumulus dispersion rate. It was found that the logarithm of the time for complete cumulus dispersion and the logarithm of hyaluronidase activity are linearly related in three incubation media. These data have been used in constructing standard curves for the prediction of hyaluronidase activity from the observed time for complete cumulus dispersion. The technique is sensitive to low levels of hyaluronidase activity, is compatible with complex incubation media, and requires small volumes of test solution.
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Talbot et al. (1974) studied this question.
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