Why the study?
Does denervation alter mRNA populations in adult rat gastrocnemius muscle?
Does denervation alter mRNA populations in adult rat gastrocnemius muscle?
This preclinical study demonstrates that motoneurons control gene expression in skeletal muscle fibers, as evidenced by marked changes in mRNA populations following denervation.
Hypothesis-generating for motoneuron-muscle gene regulation; leaves open translation to human neuromuscular disease.
The mRNA populations of control and 8-days-denervated adult rat gastrocnemius have been analysed by the translation assay and the cDNA-mRNA molecular hybridization technique. This analysis demonstrates the appearance of marked changes in many of the mRNA sequences present in muscle fibres following denervation and thus gives strong support to the hypothesis that the motoneurons are able to control the gene expression of muscle fibres.
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Metafora et al. (1980) studied this question.
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