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Apolipoprotein alterations may guide dyslipidemia evaluation; leaves open causal validation and targeted interventions in prospective studies.
Some of the major advances in the field of lipoprotein research during the past decade concern the elucidation of the specific functions of the protein moieties of the lipoprotein particles, the apolipoproteins. Each lipoprotein contains one or more apolipoprotein species. The major apolipoproteins A, B, C and E, for their part, consist of a family of one or more immunologically distinct proteins. Apart from being structural components of lipoproteins that are important for the solubilisation of cholesterol and triglycerides, apolipoproteins serve as cofactors for enzymes essential for lipoprotein metabolism and function as ligands for the binding of lipoproteins to high-affinity cellular receptors. Accordingly, disturbances of lipoprotein metabolism can often be explained by alterations in the structure or function of apolipoproteins.
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Anders Hamsten (1988) studied this question.
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