Experimental Peptic Ulcer Produced by Cinchophen

Cinchophen has been used since 1911 in the treatment of gout. Toxic cirrhosis of the liver has developed in a few cases after its use. In attempting to produce hepatic damage experimentally in dogs, Churchill and Van Wagoner1in 1931 noted peptic ulcer in many of their animals. This and subsequent work by these investigators suggested to us that we attempt to produce peptic ulcer by the administration of cinchophen. Ulceration developed readily in dogs after the administration of this drug. This led to a consideration experimentally of (1) the genesis and healing process of this type of ulcer, (2) the effect of a mechanical irritant and (3) the possibility of producing ulcer by the administration of cinchophen other than by the oral route. REVIEW OF THE LITERATURE Experimentally, the methods for the production of acute peptic ulcer have been many and relatively simple, while, on the other hand,