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A new class of a-aminophosphonic acid esters (4a-l) have been synthesized by three component one-pot reaction with equimolar quantities of 2-amino benzonitrile (1), dimethylphosphite (3) and various aldehydes (2a-l) in dry toluene at reflux conditions via Kabachnic-Fields reaction in high yields (74-85%).The structure of title compounds has been established by elemental, IR, 'H, 13C, 31P and Mass spectral analysis.They were found to possess significant anti microbial activity.
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G. Chandra Sekhar Reddy (2008) studied this question.
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