September 23, 1983Science

Turnover, Membrane Insertion, and Degradation of Sodium Channels in Rabbit Urinary Bladder

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Population

Rabbit urinary bladder

Design

Preclinical

Authors

DLDonald D. F. LooUniversity of California, Los Angeles SLSimon A. LewisThe University of Adelaide MIMark S. IfshinYale University

Discussion

Member takes

Implication

No immediate clinical implications from this rabbit model; leaves open human relevance of ENaC insertion and degradation dynamics.

Structured PICO

Population

Rabbit urinary bladder

Intervention

Hydrostatic pressure and mucosal surface washing

Outcome

Sodium channel turnover, membrane insertion, and degradation (assessed via noise analysis)surrogate

The study demonstrates that sodium channels in the rabbit urinary bladder undergo a continuous process of intracellular synthesis, insertion into the apical membrane, degradation, and elimination.

Cite This Study

Loo et al. (1983) studied this question.

synapsesocial.com/papers/6a90146e028f4c29a42b1310 https://doi.org/10.1126/science.6612343

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Turnover, Membrane Insertion, and Degradation of Sodium Channels in Rabbit Urinary Bladder

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Turnover, Membrane Insertion, and Degradation of Sodium Channels in Rabbit Urinary Bladder

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider