The possible association of clusterin fucosylation changes with male fertility disorders

Figures

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  Figure 1. The values of seminal plasma (A–C) and serum (D–F) parameters measurements. CLUPL—seminal plasma CLU concentration; FUT3PL—seminal plasma FUT3 concentration; FUT4PL—seminal plasma FUT4 concentration; CLUS—serum CLU concentration; UEAS—relative reactivity of serum CLU glycans with Ulex europaeus agglutinin; LCAS- relative reactivity of serum CLU glycans with Lens culinaris agglutinin. A two-tailed p-Value of less than 0.05 was considered significant.

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  Figure 2. Comparison of glycosylation profile in two biological fluids (seminal plasma and serum) in the study group (A–C). FUT3PL—seminal plasma FUT3 concentration; FUT3S—serum FUT3 concentration; FUT4PL—seminal plasma FUT4 concentration; FUT4S—serum FUT4 concentration; UEAPL—relative reactivity of CLU glycans with Ulex europaeus agglutinin in seminal plasma; UEAS—relative reactivity of CLU glycans with Ulex europaeus agglutinin in serum. The correlations were calculated using the Spearman rank test and a two-tailed p-Value of less than 0.05 was considered significant. The dashed line points 95% of confidence interval.

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  Figure 3. Receiver operating characteristic (ROC) curves for seminal plasma parameters with the area under the curve (AUC) higher than 0.700 (A–F). CLUPL—seminal plasma CLU concentration; FUT3PL—seminal plasma FUT3 concentration; FUT4PL—seminal plasma FUT4 concentration.

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  Figure 4. Receiver operating characteristic (ROC) curves for serum parameters with the area under the curve (AUC) more than 0.700 (A–K). CLUS—serum CLU concentration; FUT4S—serum FUT4 concentration; UEAS-relative reactivity of serum CLU glycans with Ulex europaeus agglutinin; LCAS-relative reactivity of serum CLU glycans with Lens culinaris agglutinin.