Effects of three different methods of anesthesia on the release of brain natriuretic peptid in patients with cardiac risk undergoing lower extremity surgery

Canan Atalay; Celalettin Dağlı; Ednan Bayram; HACI AHMET ALICI; Alı Fuat Erdem; Mevlüt Sait Keleş; Şahin Yüksek

doi:10.3906/sag-0907-91

January 1, 2010TURKISH JOURNAL OF MEDICAL SCIENCESOpen Access

Effects of three different methods of anesthesia on the release of brain natriuretic peptid in patients with cardiac risk undergoing lower extremity surgery

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Why the study?

Does thoracal epidural analgesia combined with general anesthesia reduce plasma BNP concentrations in patients with CAD risk undergoing lower extremity surgery compared to general anesthesia alone?

Structured PICO

Does thoracal epidural analgesia combined with general anesthesia reduce plasma BNP concentrations in patients with CAD risk undergoing lower extremity surgery compared to general anesthesia alone?

P

Population

60 patients who were at risk for, or had, coronary artery disease (CAD) and scheduled to undergo lower extremity surgery.

I

Intervention

General anesthesia combined with intra and postoperative thoracal epidural analgesia as well as I.V PCA (Group T, n=20) OR lumbar epidural anesthesia followed by lumbar epidural analgesia (Group L, n=20).

C

Comparator

General anesthesia followed by intravenous patient-controlled analgesia (I.V PCA) (Group G, n=20).

O

Outcome

Plasma concentrations of brain natriuretic peptide (BNP) measured preoperatively, 90 min after skin incision, towards the end of surgery, and in the morning of day 1, 2, and 3 postoperation.surrogate

Implication

Thoracal epidural analgesia combined with general anesthesia blunts the postoperative rise in BNP compared to general or lumbar epidural anesthesia in patients with CAD risk undergoing lower extremity surgery.

Abstract

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Cite This Study

Atalay et al. (2010) studied this question.

synapsesocial.com/papers/6a9016edf009383eee8406dc https://doi.org/10.3906/sag-0907-91

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Effects of three different methods of anesthesia on the release of brain natriuretic peptid in patients with cardiac risk undergoing lower extremity surgery

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Effects of three different methods of anesthesia on the release of brain natriuretic peptid in patients with cardiac risk undergoing lower extremity surgery

Structured PICO

Implication

Abstract

Discussion

Cite This Study

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