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A rapid method for the determination of paracetamol in human blood serum using first-derivative UV absorption spectroscopy is described. It involves no sample pretreatment, extraction or derivatization procedures, other than a standard deproteinizing technique with trichloroacetic acid. The results can be applied to both therapeutic and toxic levels of paracetamol.
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Damiani et al. (1995) studied this question.
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