Effect of a Catechol Amine Blocking Agent (Dibenzyline) on Organ Content and Urine Excretion of Noradrenaline and Adrenaline

Summary. 1. The urinary excretion of noradrenaline and adrenaline was determined in normal rats and rats receiving dibenzyline. The effect of this blocking agent on the catechol content of the adrenals, heart and spleen was also observed. 2. Dibenzyline caused an increased excretion of noradrenaline, and a decreased organ content of catechols. Urinary adrenaline remained unchanged. 3. The significance of these findings is discussed in the light of the effector catechol receptor theory. It is suggested that dibenzyline may interfere with the metabolism of catechols in areas not contiguous to their site of production.