Nephropathy Associated with the Use of Analgesic Medications

Article1 April 1965Nephropathy Associated with the Use of Analgesic MedicationsJOHN V. YOUNG, M.D., GLEN B. HAYDON, M.D., CARY P. GRAY, M.D., SYDNEY P. HECKER, M.D., PHILIP R. LEE, M.D.JOHN V. YOUNG, M.D.Search for more papers by this author, GLEN B. HAYDON, M.D.Search for more papers by this author, CARY P. GRAY, M.D.Search for more papers by this author, SYDNEY P. HECKER, M.D.Search for more papers by this author, PHILIP R. LEE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-4-727 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough nephropathy associated with the use of analgesic medication has received wide notice recently, detailed study and long-term follow-up study of patients reputed to have this problem are rare. We, therefore, present this report on three patients carefully studied and followed up for up to 22 months. Renal biopsy specimens were obtained in two of the patients; tissue from one patient was studied by electron microscopy. The literature is reviewed briefly and some aspects of pathogenesis discussed.CASE REPORTSCASE 1A 31-year-old white woman was seen October 30, 1959, complaining of headaches since the age of 6. She admitted...References1. SPÜHLERZOLLINGER OHU: Die chronischinterstitielle nephritis. Z. Klin. Med. 151: 1, 1953. MedlineGoogle Scholar2. ZOLLINGER HU: Die Interstitielle Nephritis, Karger, Basel, 1945. Google Scholar3. MOESCHLIN S: Phenacetinsucht und-schäden innenkörperanämien und interstitielle nephritis. Schweiz. Med. Wschr. 87: 123, 1957. MedlineGoogle Scholar4. LlNDENEGFlSHERPEDERSENNISSEN OSJNJ: Necrosis of renal papillae and prolonged abuse of phenacetin. Acta Med. Scand. 165: 321, 1959. CrossrefMedlineGoogle Scholar5. MOOLTENSMITH SEIB: Fatal nephritis in chronic phenacetin poisoning. Amer. J. Med. 28: 127, 1960. CrossrefMedlineGoogle Scholar6. 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LinkGoogle Scholar33. SPÜHLER O: Die Chronische Pyelonephritis. Schweiz. Med. Wschr. 91: 1079, 1961. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN V. YOUNG, M.D.; GLEN B. HAYDON, M.D.; CARY P. GRAY, M.D.; SYDNEY P. HECKER, M.D.; PHILIP R. LEE, M.D.Affiliations: Palo Alto, CaliforniaFrom the Department of Medicine and Urology, Palo Alto Medical Clinic, and the Experimental Pathology Division, Palo Alto Medical Research Foundation, Palo Alto, Calif.Requests for reprints should be addressed to John V. Young, M.D., Palo Alto Medical Clinic, 300 Homer Ave., Palo Alto, Calif. 94301. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChronic Interstitial Nephritis: Etiologic FactorsT. MURRAY, M.D., M. GOLDBERG, M.D., F.A.C.P.Nephropathie durch AnalgeticaANALGESIC ABUSE IN PSYCHIATRIC PATIENTSSyndrome Associated with the Abuse of AnalgesicsM. HENRY GAULT, M.D., M.SC., F.A.C.P., T. CHRISTOPHER RUDWAL, M.D., W. DENNIS ENGLES, B.SC., M.D., JOHN B. DOSSETOR, M.A., B.M., B.CH., PH.D., F.R.C.P.(C)Analgesic NephropathyPRISCILLA KINCAID-SMITH, M.B., F.R.A.C.P., D.C.P.Ricerche Sperimentali Sulla Necrosi da Fenacetina Delle Papille RenaliRenal Papillary Necrosis following Phenacetin ExcessRenal Papillary Necrosis: a Critique of PathogenesisPhenacetin Nephropathy in a Mother and DaughterPhenacetin, aspirin, and kidney damageBlood Clotting Studies in a Submarine Crew 1 April 1965Volume 62, Issue 4Page: 727-737KeywordsAnalgesicsBiopsyElectron microscopyIngestionNecrosisNephritisPathogenesisPyelonephritisUrology ePublished: 1 December 2008 Issue Published: 1 April 1965 PDF downloadLoading ...