Photodynamic inactivation of cells is caused by damage to the regions proximal to the cell envelope or to the DNA via a singlet oxygen mechanism. For penetrating dyes the possibility of either type of damage remains. The contribution of a penetrating dye. acriflavine. remaining outside E. coli B/r cells during irradiation. towards photodynamic inactivation was investigated. It was found that this contribution was either nil or negligible.
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Bagchi et al. (1979) studied this question.
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