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Demonstrates consistent, severe impairment of cerebral blood flow using three-vessel occlusion in rats, indicating an effective alternative stroke model.
A new model of bilateral hemispheric ischemia was created in the rat by occluding the common carotid arteries and the basilar artery; this resulted in consistent and severe impairment of the cerebral blood flow. The procedure for producing this model is described, and the results of EEG and autoradiography obtained by this model are compared to those obtained by the four-vessel occlusion model.
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Kameyama et al. (1985) studied this question.
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