NO2 10 C OH m-Nitrobenzoic acid (MNB) is widely used in explosive and dyestuff industries and also as a chemical intermediate in organic syn- theses. In a 90-day prechronic study, both F344 rats and B6C3F1 mice exposed to high concentrations of MNB exhibited tes- ticular atrophy and reduced sperm count. This RACB study using Swiss CD-1 mice was performed as a follow-up to that origi- nal observation. Data from a 2-week doserange-finding study (Task 1) were used to set exposure concentrations for the Task 2 continuous cohabitation study at 0.35, 0.75, and 1.5% in feed. Based on mean feed consumption and body weight, the estimated daily dosages were approximately 0.5, 1.3, and 2.8 g/kg/day.
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A 1997 study studied this question.