It has been reported by several investigators that increased blood production accompanying haemolytic disease is usually associated with folate deficiency (Chanarin, Dacie and Mollin, 1959). In many such instances the bone marrow shows megaloblastic transformation which reverts to normal following treatment with folic acid (Chanarin et al., 1959). It therefore seemed of interest to study the effect of experimentally induced bone marrow proliferation on the requirement and distribution of various folate metabolites in the blood, serum, bone marrow and liver tissue. The present study deals with the results of such investigations in the rat following repeated massive bleeding and phenylhydrazine injections.
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Izak et al. (1966) studied this question.
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