Ferreira & Vane (1967) have shown that less than 30% of bradykinin infused into the right atrium emerges in the ascending aorta.In blood the biological half-life was found to be 17 sec.Consider- ing the brief circulation time from right atrium to ascending aorta (2-lOsec.;Spector, 1956), they concluded that enzymes of blood could not account for the degree of inactivation that occurred in the pulmonary circulation.
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Ryan et al. (1968) studied this question.
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