The Maximal Tubular Transfer of Glucose and Para‐amino‐hippurate in Premature Infants1,2

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Summary The maximal tubular excretion of para‐amino‐hippurate (TmpAH) and the maximal tubular reabsorption of glucose (Tmc) have been determined in 7 premature infants aged 19–135 days. An infusion technique was used by which it was possible to change the water administration during the experiment. With urine flows above 3 ml/min. per 1.73 sq.m. the values of TmpAH and Tmo seemed to be independent of the urine flow. With lower urine flows the results were unreliable. Tmo increased with increasing age, in spite of the oldest infants being those with the lowest birth weights. The ratio inulin clearance/TmG was higher than in adults, indicating that in the newborn premature infant the tubuli are more immature than the glomeruli. Similar changes with regard to TmpAH were less evident.