Key result
Magnesium pretreatment significantly reduced the mean onset of action of cisatracurium compared to control (4.27 vs 5.48 minutes) in cardiac surgery patients.
Why the study?
An ideal neuromuscular blocking agent requires rapid onset, short duration, and no adverse hemodynamic effects, prompting evaluation of whether magnesium pretreatment affects cisatracurium blockade and hemodynamics during cardiac surgery on cardiopulmonary bypass.
Does magnesium sulfate pretreatment improve the onset and duration of cisatracurium-induced neuromuscular blockade in cardiac surgery patients on cardiopulmonary bypass?
RCT (n=60)
double blind
randomized
No
Does magnesium sulfate pretreatment improve the onset and duration of cisatracurium-induced neuromuscular blockade in cardiac surgery patients on cardiopulmonary bypass?
Absolute Event Rate: 4.27% vs 5.48%
Magnesium sulfate pretreatment significantly accelerates the onset and prolongs the duration of cisatracurium-induced neuromuscular blockade in cardiac surgery patients without adverse hemodynamic effects.
May warrant consideration for faster blockade in cardiac anesthesia; leaves open effects on intubation outcomes.
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Naqvi et al. (2020) conducted an RCT in cardiac surgery on cardiopulmonary bypass (n=60). Magnesium pretreatment vs. 100ml NS 10 mins before general anesthesia, followed by cisatracurium 0.2mg/kg was evaluated on mean onset of action of injection cis-atracurium. Magnesium pretreatment significantly reduced the mean onset of action of cisatracurium compared to control (4.27 vs 5.48 minutes) in cardiac surgery patients.
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