Why the study?
Does combined pretreatment with lidocaine and ephedrine improve tracheal intubation conditions and onset time of rocuronium in adults undergoing general anesthesia?
Does combined pretreatment with lidocaine and ephedrine improve tracheal intubation conditions and onset time of rocuronium in adults undergoing general anesthesia?
Pretreatment with a combination of ephedrine and lidocaine significantly improves tracheal intubation conditions 45 seconds after rocuronium administration without causing adverse hemodynamic effects.
Supports combined lidocaine-ephedrine pretreatment for superior intubation conditions; confirms safe adjunctive role in rocuronium anesthesia without onset benefit.
Background: Rocuronium is a nondepolarizing muscle relaxants used for trying rapid-sequence intubation due to its relatively rapid onset of action and low side effects. Methods to further reduce the onset time of a muscle relaxant include increasing the dose of muscle relaxant, pretreatment for potentiating neuromuscular block of the muscle relaxants or increasing the cardiac output and muscle blood flow. The purpose of this study was to examine the pretreatment effect of combined lidocaine and ephedrine, as a pretreatment, on the onset time and intubation conditions of rocuronium-induced neuromuscular block in adults.
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Kim et al. (2007) studied this question.
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