Four‐bond H8/H6‐H1 scalar coupling correlations in two‐dimensional correlated spectroscopy have been observed directly for the first time by using the J‐scaled COSY [(1985) Chem. Phys. Lett. 116, 105‐108] technique in a dinucleotide, cytidylyl(2'–5')guanosine (CpG). Unambiguous resonance assignment of nonexchangeable protons in CpG has been obtained using these H8/H6‐H1' 4‐bond correlations and the various 3‐ and 4‐bond sugar ring proton correlations observed in the COSY and SUPER COSY experiments.
No takes yet. Share an insight, caveat, or question.
Gundhi et al. (1985) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: