Answers are grounded in this paper and cite their sources.
A simple, sensitive, reproducible, and rapid high performance liquid chromatographic assay, with column switching, is described for the determination of cefazolin in human serum. Serum samples were directly injected, first, in a chromatographic column for sample clean-up and extraction, and then, analysed on a analytical column using ultraviolet absorption at 273 nm. The assay allows direct determination of cefazolin over the range of 1 - 250 μg/mL using 12.5 μL of serum. Validation of the method demonstrated a good sensitivity, accuracy, and precision. It has been applied to study the pharmacokinetics of the drug in patients undergoing vascular surgery.
No takes yet. Share an insight, caveat, or question.
Bompadre et al. (1998) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: