Strain differences in susceptibility to the teratogenic effect of acetazolamide in mice

Intraperitoneal administration of acetazolamide to pregnant female mice on day 9 or 10 of gestation (750 mg/kg given twice, at 10 AM and 4 PM) produced postaxial abnormalities of the forelimbs with high frequency in the CBA/J and C57BL/6J strains, intermediate frequency in A/J and DBA/2J, and low frequency in C3H/HeJ and SWR/J. CBA/J was most susceptible to treatment on day 10, A/J on days 9 and 10, and C57BL/6J and C3H/HeJ on day 9. There was no reduction in amount of amniotic fluid 4 h after the last injection.