Why the study?
Does dopamine agonist therapy prevent rapid death in cocaine overdose compared to dopamine antagonists?
Population
Cocaine abusers experiencing rapid death or overdose
Comparison
Dopamine agonists (proposed treatment) vs Dopamine antagonists (standard treatment)
Authors
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Hypothesis-generating for dopamine agonists in cocaine overdose; should not change practice pending trials.
Does dopamine agonist therapy prevent rapid death in cocaine overdose compared to dopamine antagonists?
This hypothesis suggests that rapid death in cocaine abuse may be a variant of neuroleptic malignant syndrome, fundamentally altering the proposed pharmacological management from dopamine antagonists to dopamine agonists.
Kosten et al. (1988) studied this question.
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