The effects of several noncollagenous matrix proteins on hydroxyapatite formation and growth were studied in a dynamic collagen gel system. In this system growth plate proteoglycan aggregates at concentrations of 1-10 micrograms/ml were effective inhibitors, desulfated aggregates from brachymorphic mice were less effective. Phosphophoryn at 1-100 micrograms/ml had no effect on formation; 60-120 micrograms/ml retarded mineral growth. Type X collagen at concentrations of 50-300 micrograms/ml had no effect on formation or growth.
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Boskey et al. (1989) studied this question.
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