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The prostaglandin synthesis inhibitor indomethacin (used as a suppository) was compared to placebo in the treatment of primary nocturnal enuresis in a double-blind crossover study. There were 12 girls and 7 boys between 6 and 15 years old. Indomethacin (50 to 100 mg.) was significantly more effective than placebo in the treatment of primary enuresis.
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Noori S. Al‐Waili (1989) studied this question.
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