Why the study?
Measurement of total vitamin B12 raised concerns over early detection of deficiency due to clinical unreliability, prompting an assessment of active vitamin B12 efficacy.
Does active vitamin B12 measurement improve diagnostic accuracy for true vitamin B12 deficiency compared to total vitamin B12 in patients referred for testing?
Population
100 participants referred for vit B12 assay
Comparison
Active vit B12 vs total vit B12
Design
Retrospective study
Key result
Active vitamin B12 demonstrated higher sensitivity (82.35% vs 65%) and specificity (46.6% vs 43.8%) compared to total vitamin B12 for diagnosing true vitamin B12 deficiency.
Authors
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Active B12 may aid deficiency detection in referred patients; leaves open need for prospective outcome validation before routine adoption.
Observational (n=100)
No
Does active vitamin B12 measurement improve diagnostic accuracy for true vitamin B12 deficiency compared to total vitamin B12 in patients referred for testing?
Absolute Event Rate: 82.35% vs 65%
Active vitamin B12 (holo-transcobalamin) is a more sensitive and specific biomarker than total vitamin B12 for the early and accurate diagnosis of vitamin B12 deficiency.
Dastidar et al. (2022) conducted an observational in Vitamin B12 deficiency (n=100). Active vitamin B12 (holo-transcobalamin) assay vs. Total vitamin B12 assay was evaluated on Sensitivity for true vitamin B12 deficiency. Active vitamin B12 demonstrated higher sensitivity (82.35% vs 65%) and specificity (46.6% vs 43.8%) compared to total vitamin B12 for diagnosing true vitamin B12 deficiency.