According to a number of authors, the response of an organ after local irradiation depends not only on the X-ray dose administered to and absorbed by this organ but also on the dose received by other tissues (1-4). This fact is explained as an effect at a distance (or abscopal effect, 5) of irradiated tissues. Jolles (1, 2), for instance, showed that the erythema skin reaction in man is more intense when irradiated fields are close to each other than when they are further apart. According to Rausch (3), the epilatory effect of X-rays in guinea pigs is enhanced by an increase in the irradiated volume. Devik (6) greatly diminished the skin reaction of hairless mice by protecting small surfaces. The purpose of this investigation was to study the variations in the percentage of dysplastic hair (7, 8) in young mice after irradiation to try to demonstrate an analogous phenomenon.
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Caneghem et al. (1965) studied this question.