Ultimate coupling partners: Widely available enolizable aldehydes and ketones undergo Sonogashira cross-coupling with other carbonyl compounds to give conjugated enynes in a newly devised general method (see scheme; NfF=nonafluorobutane-1-sulfonyl fluoride). The synthetic protocol comprises at least four operating steps, which are carried out in one pot using common reagents, catalysts, and additives.
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Lyapkalo et al. (2006) studied this question.
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