Two fully automated synthetic procedures of [18F]fluoroacetate ([18F]FAC) have been developed using a modified commercial TRACERlab FXFN synthesizer. One was a two‐step one‐pot procedure, consisting of nucleophilic [18F]fluorination of benzyl‐2‐bromoacetate as a precursor with no‐carrier‐added [18F]fluoride, hydrolysis within the same [18F]fluorination reaction vessel, and purification with/without high‐performance liquid chromatography (HPLC). The second procedure consisted of nucleophilic [18F]fluorination, hydrolysis on the column, and purification with SEP‐PAK cartridges instead of HPLC. The radiochemical purity of [18F]FAC was >95% by the two procedures. The second procedure was a simple, rapid, and fully automated synthesis of [18F]FAC with a high and reproducible radiochemical yield exceeding 60% (decay uncorrected) within the total synthesis time less than 20 min. The new, simple, and rapid on‐column hydrolysis procedure should be adaptable to the fully automated synthesis of [18F]FAC at a commercial fluoro‐deoxyglucose synthesis module.
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Tang et al. (2008) studied this question.