A Pilot Study of Normative Data for Macular Thickness and Volume Measurements Using Cirrus High-Definition Optical Coherence Tomography

In Brief Purpose: To establish preliminary normative data for macular thickness (MT) and macular volume (MV) by Cirrus high-definition optical coherence tomography (Carl Zeiss Meditec, Dublin, CA). Methods: Retrospective case series of 192 eyes of 192 subjects (age, 20–90 years) without retinal disease or surgery with best-corrected visual acuity ≥20/25, intraocular pressure <21 mmHg, and cup-to-disc ratio ≤0.5 were enrolled. Retinal thicknesses in nine Early Treatment Diabetic Retinopathy Study subfields (including central subfield thickness [CST]), MT, and MV were measured with Cirrus high-definition optical coherence tomography. Effects of age, gender, lens status, and diabetic status on these measurements were analyzed. Results: The mean ±SD CST, MT, and MV were 262.4 ± 22.8 μm, 281.3 ± 14.5 μm, and 10.1 ± 0.6 mm3, respectively. Although CST and age were not associated (P = 0.45), both mean MT and mean MV declined with age (P < 0.0001). Central subfield thickness (P = 0.002), mean MT (P = 0.021), and MV (P = 0.041) were higher in men compared with women. Neither lens status nor diabetic status affected CST, MT, or MV. Conclusion: A pilot study showed that preliminary normative CST, MT, and MV values were obtained by Cirrus high-definition optical coherence tomography. The authors propose that CST ranges from 216.8 μm to 308 μm in normal eyes. Older age and female gender were associated with thinner MT. Preliminary normative central subfield thickness, macular thickness, and macular volume values were obtained by Cirrus high-definition optical coherence tomography. We propose that central subfield thickness ranges from 216.8 μm to 308 μm in normal eyes. Older age and female gender were associated with thinner macular thickness.