HHV-6 is an emerging neuro- and lymphotropic virus with multiple disease associations

This is the authors' abstract. We don't add key points for this paper.

Human herpesvirus 6 (HHV-6) is a highly neuro- and lymphotropic virus with an increasing number of diseases associated with it. Most children are infected at the age of 6 to 15 months. Primary infection manifests classically as exanthema subitum. This is, however, only one aspect of the clinical spectrum of the disease. Neurological symptoms are common and the virus may persist in several tissues and cells and be reactivated in various immunosuppressive conditions. In addition, HHV-6 may be involved in many chronic diseases. The two variants HHV-6A and HHV-6B appear to have different disease associations. To conclude, diseases associated with or caused by HHV-6 seem to expand. HHV-6 needs attention and active research both in children and in adults.