Why the study?
Neonatal epileptic encephalopathy caused by KCNQ2 mutations is difficult to treat, partially because the effects of KCNQ2 mutations on human neuronal development and function are unknown.
Population
Patient-derived neurons generated from induced pluripotent stem cells and gene editing
Comparison
Patient-derived neurons vs control neurons
Design
In vitro disease model study using electrophysiological and optical approaches
Key result
The authors have withdrawn their manuscript to perform additional experiments and request that the work not be cited.
Authors
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Withdrawn manuscript should not guide practice or be cited; leaves open the research question pending re-submission.
Simkin et al. (2019) studied KCNQ2 Encephalopathy. The authors have withdrawn their manuscript to perform additional experiments and request that the work not be cited.
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