Why the study?
Does indomethacin reduce the duration of fever and associated symptoms in patients with unexplained postoperative fever following cardiac surgery?
Population
67 patients with unexplained postoperative fever following cardiac surgery
Comparison
Indomethacin 100 mg per day for 7 days vs Placebo for 7 days
Design
RCT, randomized, double-blind
Follow-up
2-8 months following hospital discharge
Authors
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Indomethacin shortens unexplained postoperative fever after cardiac surgery; supports its use and extends NSAID evidence in this setting.
Does indomethacin reduce the duration of fever and associated symptoms in patients with unexplained postoperative fever following cardiac surgery?
Indomethacin significantly reduces the duration of unexplained fever and associated symptoms following cardiac surgery compared to placebo.
Livelli et al. (1978) studied this question.
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