Answers are grounded in this paper and cite their sources.
The relative and absolute configuration of the cytotoxic myriaporones (e.g. 4) was assigned by their total synthesis from aldehyde 1. Key steps included aldol reactions with chiral oxazolidinone 2 and with Weinreb amide 3. TBS=tert-butyldimethylsilyl, PMB=p-methoxybenzyl.
No takes yet. Share an insight, caveat, or question.
Pérez et al. (2004) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: