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Background and Objectives: Pseudomonas aeruginosa is an important nonfermenting gram-negative hospital-acquired pathogen. Treatment of P. aeruginosa infections has become more challenging due to overexpression of efflux pumps. The aim of the present study was to apply in silico analysis to evaluate the structure of the efflux pump regulatory protein, MexR, and impact of mutation on its stability and function.
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Vaez et al. (2017) studied this question.
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