The Jarisch-Herxheimer reaction in trypanosomiasis with a note on the morular cells of mott

The postmortem changes in the brain of a man who suffered from a recent Trypanosoma rhodesiense infection are described. The patient who had previously shown severe nervous symptoms died in coma the day after receiving 2 grammes of tryparsamide. Parts of the caudate and lenticular nuclei were found to be the seat of widespread haemorrhages which were due to a confluence of punctate haemorrhages producing a massive effect. The pathogeny of the Jarisch-Herxheimer reaction is discussed in its relation to syphilis and to cerebral trypanosomiasis. A note is added on the appearance and nature of the morular cells of Mott which were especially numerous in the second case of sleeping sickness.