TiCl4: An efficient catalyst for one-pot synthesis of 1,2-dihydro-1-aryl-naphtho-[1,2-e][1,3]oxazin-3-one derivatives and their drug score analysis

Multi-component, economical and efficient synthesis of 1,2-dihydro-1-aryl-naphtho[1,2- e ][1,3]-oxazin-3-one derivatives ( 4a – k ) with an excellent yield is described through a one-pot condensation of β-naphthol, aromatic aldehydes and urea in presence of catalytic amount of TiCl 4 (10 mol%) under conventional heating and microwave irradiation. The role of catalyst in the conversion of reactants to the final compounds is described. All the compounds have been characterized by spectral (IR, 1 H, 13 C NMR and Mass) and analytical data. The pharmacological parameters of title compounds were also analyzed for their bioavailability by Osiris property explorer.