Key result
Treatment with an antithyroid drug, beta-adrenergic blocker, and potassium supplementation successfully resolved symptoms and maintained a euthyroid state in a 14-year-old girl with thyrotoxic periodic paralysis.
Case Report (n=1)
Thyrotoxic periodic paralysis should be considered in children presenting with acute skeletal muscle paralysis and hypokalemia, warranting evaluation of thyroid function.
May support this regimen in rare pediatric cases; leaves open confirmation of efficacy and safety in larger cohorts.
Thyrotoxic periodic paralysis (TPP) is a rare complication of hyperthyroidism characterized by recurrent paralysis of skeletal muscle and hypokalemia caused by a massive intracellular shift of potassium. TPP mainly affects young male patients of Asian descent. We describe a case of TPP in a 14-year-old girl who presented with palpitation and intermittent weakness of the lower extremities especially after physical exercises. The patient showed sinus tachycardia, proximal weakness of both legs and a severe hypokalemia. Thyroid function tests showed hyperthy- roidism, and thyroid scan revealed diffusely enlarged goiter consistent with Graves' disease. After the management with antithyroid drug, beta-adrenergic blocker and potassium supplementation for TPP, she has remained euthyroid state and symptom free on the follow-up. TPP should be considered in children with acute paralysis of skeletal muscle and hypokalemia, also thyroid function should be evaluated.
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Oh et al. (2011) conducted a case report in Thyrotoxic periodic paralysis and Graves' disease (n=1). Antithyroid drug, beta-adrenergic blocker, and potassium supplementation was evaluated on Symptom resolution and euthyroid state. Treatment with an antithyroid drug, beta-adrenergic blocker, and potassium supplementation successfully resolved symptoms and maintained a euthyroid state in a 14-year-old girl with thyrotoxic periodic paralysis.
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