Intra-amniotic L-thyroxine can successfully manage amiodarone-induced fetal hypothyroidism.
Does not support practice change for fetal hypothyroidism; leaves open the role of intra-amniotic L-thyroxine pending controlled data.
We present a case of persistent fetal supraventricular tachycardia where transplacental and direct fetal treatment with amiodarone caused an iatrogenic hypothyroidism. This condition was successfully managed with the intra-amniotic instillation of 250 micrograms of L-thyroxine weekly, for 3 weeks. A male infant was delivered at 32 weeks by Caesarean section. The neonatal electrocardiogram showed Wolf-Parkinson-White (WPW) syndrome, which was controlled by digoxin alone. Thyroid function normalized quickly and the baby is developing normally.
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Catte et al. (1994) studied this question.
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